Salarin c synthesis
WebNov 2, 2024 · The synthesis of the macrocyclic core of the cytotoxic natural product salarin C from the sponge Fascaplysinopsis sp. is described, with the two epoxides being … WebA convergent strategy for the synthesis of dideoxysalarin C (3) as a potential intermediate for the total synthesis of the marine macrolide salarin C (1) is described.
Salarin c synthesis
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WebA convergent strategy for the synthesis of dideoxysalarin C (3) as a potential intermediate for the total synthesis of the marine macrolide salarin C (1) is described.The macrolactone core of 3 was assembled by Suzuki coupling between alkyl iodide 9 and vinyl iodide 8 and Shiina macrolactonization as key transformations. All macrocyclic intermediates were … WebAug 17, 2024 · While salarin C (SalaC) is a potent marine cytotoxin, Kashman demonstrated that congeners which had undergone Wasserman rearrangement exhibit little to no …
WebWhile salarin C (SalaC) is a potent marine cytotoxin, Kashman demonstrated that congeners which had undergone Wasserman rearrangement exhibit little to no cytotoxicity. Given … WebMay 5, 2024 · The synthesis was inspired by Kashman's hypothesis on the biomimetic oxidation of salarin C to salarin A. Clean conversion to the triacylamine partial structure of salarin A occurred on treatment with photochemically generated singlet oxygen. Thus, a Wasserman-type oxidative rearrangement is chemically possible in this case.
WebNov 12, 2013 · In the course of studies on bioactive metabolites from marine fungi, a new 10-membered lactone, named penicillinolide A (1) was isolated from the organic extract of Penicillium sp. SF-5292 as a potential anti-inflammatory compound. The structure of penicillinolide A (1) was mainly determined by analysis of NMR and MS data and Mosher’s … WebNov 1, 2013 · Derivatives of salarin A, salarin C and tulearin A were prepared and bio-evaluated as inhibitors of K562 leukemia cells and interesting preliminary SAR (structure activity relationship) information was obtained from the products. Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were …
WebNov 26, 2024 · Abstract. A convergent strategy for the synthesis of dideoxysalarin C (3) as a potential intermediate for the total synthesis of the marine macrolide salarin C (1) is described. The macrolactone core of 3 was assembled by Suzuki coupling between alkyl iodide 9 and vinyl iodide 8 and Shiina macrolactonization as key transformations.
WebDec 7, 2024 · A convergent strategy for the synthesis of dideoxysalarin C (3) as a potential intermediate for the total synthesis of the marine macrolide salarin C (1) is described. The macrolactone core of 3 was assembled by Suzuki coupling between alkyl iodide 9 and … discount tire and auto oshawaWebAug 17, 2024 · Europe PMC is an archive of life sciences journal literature. Search life-sciences literature (41,975,589 articles, preprints and more) (41,975,589 articles, preprints and more) fowey art shopWebNov 26, 2024 · Abstract. A convergent strategy for the synthesis of dideoxysalarin C (3) as a potential intermediate for the total synthesis of the marine macrolide salarin C (1) is … fowey artistfowey art trailWebOct 24, 2024 · The synthesis of the macrocyclic core of the cytotoxic natural product salarin C from the sponge Fascaplysinopsis sp. is described, with the two epoxides being … discount tire and automotive warehouse saleWebAug 17, 2024 · Synthesis of a simplified macrocyclic analogue of cytotoxic natural product salarin C for use in stability studies. ... While salarin C (SalaC) is a potent marine cytotoxin, ... discount tire and brake henderson txWebNov 11, 2013 · Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl … fowey art